Enantioselective total synthesis of (+)-gigantecin: exploiting the asymmetric glycolate aldol reaction.
نویسندگان
چکیده
The enantioselective synthesis of the potent, selective, cytotoxic, annonaceous acetogenin, (+)-gigantecin, has been completed. An asymmetric glycolate aldol serves to establish the stereocenters at C13,14 and at C21,22. A Carreira asymmetric acetylide addition is used to establish the C17 stereocenter.
منابع مشابه
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 126 40 شماره
صفحات -
تاریخ انتشار 2004